Bock Nutritionals

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Experience wellness through our leading vitamin, mineral, and herbal supplements!


QTY - 60 Capsules

5 MTHF ES provides 10,000 mcg of 5-MTHF (5-methyltetrahydrofolate) per serving. 5-MTHF ES is the most biologically active form of the water-soluble B vitamin, folate;  and it may be the preferred form for those with variations in digestion, absorption, or folate metabolism. Data suggest that in comparison to synthetic folic acid, 5-MTHF increases plasma folate more effectively. In this formula, 5-MTHF ES is provided as Quatrefolic®the glucosamine salt of 5-MTHF ES. Quatrefolic has demonstrated greater stability, solubility, and bioavailability when compared to calcium salt forms of 5-MTHF ES.*

  • Increased absorption
  • B vitamin (folate)
  • Supports healthy cell growth and function
  • Promotes healthy fetus development

 Folate is a B vitamin that supports a myriad of processes including healthy cell growth and function, in addition to promoting a healthy fetus development! Experience the best absorption in this Bock Nutritionals formula!

  • 60 capsules
  • Serving size: two capsules

The Science: 

Good folate status is associated with a healthy mood.[5] 5-MTHF might improve trimonoamine neurotransmitter synthesis and help maintain a sense of calmness and a healthy outlook.4[6] In non-smoking adults, higher folate levels are indicative of gum tissue strength, and a range of vitamins including folate appear to act in support of oral health mechanisms.*[7,8] Folate intake is especially important for women of child-bearing age. Studies indicate that supplementing during pregnancy supports a healthy outcome.[9] In a 2010 study, researchers concluded that if a woman exhibits certain genetic variations during pregnancy, it will lead to reduced methylation capacity and subsequent DNA hypomethylation.*[10] 


Supplement Facts

Suggested Dosage: Take one to two capsules daily, or as directed by a healthcare practitioner. 

 Serving Size: 2 Capsules

 Servings Per Container: 30


Ingredients Amount Per Serving %DV
Folate (as Quatrafolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt) 10,000 mcg DFE 2,500%


Other Ingredients: Microcrystalline cellulose, HPMC (capsule), stearic acid, magnesium stearate and silica. 


1. Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on⁣
plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. [PMID: 12600857]⁣
2. Yakut M, Ustün Y, Kabaçam G, et al. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur J Intern Med.⁣
2010 Aug;21(4):320-3. [PMID: 20603044]⁣
3. Halsted CH, Villanueva JA, Devlin AM, et al. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol. 2002⁣
Jul;27(3):169-72. [PMID: 12163145]⁣
4. Willems FF, Boers GH, Blom HJ, et al. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with⁣
coronary artery disease. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]⁣
5. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry. 2002 May;72(5):567-71. [PMID:⁣
6. Stahl, SM. Depression and bipolar disorder. 3rd ed. New York: Cambridge University Press; 2008:175-178.⁣
7. Esaki M, Morita M, Akhter R, et al. Relationship between folic acid intake and gingival health in non-smoking adults in Japan. Oral Dis. 2010⁣
Jan;16(1):96-101. [PMID: 19732352]⁣
8. Thomas DM, Mirowski GW. Nutrition and oral mucosal diseases. Clin Dermatol. 2010 Jul-Aug;28(4):426-31. [PMID: 20620760]⁣
9. Mosley BS, Cleves MA, Siega-Riz AM, et al. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid⁣
fortification in the United States. Am J Epidemiol. 2009 Jan 1;169(1):9-17. [PMID: 18953063]⁣
10. James SJ, Melnyk S, Jernigan S, et al. A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers⁣
of children with autism. Am J Med Genet B Neuropsychiatr Genet. 2010 Sep;153B(6):1209-20. [PMID: 20468076]⁣

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