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QTY - 60 Tablets
5-HTP TR has a delivery system that releases 5-HTP slowly and steadily over a period of time. 5-HTP is a drug-free amino acid derived from a plant that naturally increases the body’s level of serotonin, the chemical messenger that affects emotions, behavior, appetite, and sleep.
- Pharmaceutical free
- Supports healthy serotonin levels
- Promotes healthy sleep, appetite, and emotions
Mood and Comfort- Serotonin regulates many normal brain activities, increases norepinephrine and dopamine, and is important in regulating mood and behavior. Adequate levels of serotonin are associated with normal calmness and relaxation.*[1-5]
Appetite Used in a high dose (i.e., 300 mg/three times a day), 5-HTP decreased food consumption and reduced weight. This result may relate to the effect of 5-HTP in supporting normal hypothalamic regulation, which includes appetite homeostasis. However, nausea at this relatively high dose was a common complaint. [12,13] In other research, sublingual 5-HTP administered five times per day for eight weeks in adult overweight women significantly supported feelings of post-meal hunger satisfaction.*
Hormones and Sleep 5-HTP is thought to effect the HPA axis, as it has the ability to raise plasma cortisol levels, to cause transient increase in growth hormone (at 150 mg dose), and in men only, to support healthy levels of thyroid stimulating hormone.[15,16] Serotonin is also converted to melatonin; thus, supplementation has similar effects. Support of sleep quality is likely related to 5-HTP’s ability to increase the length of rapid eye movement (REM).[3,17] In children, supplementation with 5-HTP may help modulate arousal level and support peaceful sleep.*
Experience a time-released 5-HTP health supplement that not only supports healthy serotonin levels, but promotes sleep, a balanced appetite, and mood!
- 60 tablets
- Serving size: 1 tablet
Suggested Use: Take 1 tablet, up to two times daily, with a meal. Do not exceed recommended dose.
Serving Size: 1 Tablet
Serving Per Container: 60
|Ingredients||Amount Per Serving||%DV|
|Calcium (as dicalcium phosphate)||22 mg||**|
|5-HTP (5-Hydroxytryptophan) (from Griffonia simplicifolla seed)||100 mg||**|
Other Ingredients: Cellulose, hypromellose, steric acid, silica, magnesium stearate, methylcellulose and glycerine.
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2. Gutknecht L, Jacob C, Strobel A, et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.
Int J Neuropsychopharmacol. 2007 Jun;10(3):309-20. [PMID: 17176492]
3. Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271-80. [PMID: 9727088]
4. Agren H, Reibring L, Hartvig P, et al. Low brain uptake of L-[11C]5-hydroxytryptophan in major depression: a positron emission tomography study on patients
and healthy volunteers. Acta Psychiatr Scand. 1991;83(6):449-55. [PMID: 1882697]
5. Zmilacher K, Battegay R, Gastpar M. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression.
Neuropsychobiology. 1988;20(1):28-35. [PMID: 3265988]
6. Caruso I, Sarzi Puttini P, Cazzola M, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int
Med Res. 1990 May-Jun;18(3):201-09. [PMID: 2193835]
7. Puttini S, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res. 1992 Apr;20(2):182-89. [PMID: 1521674]
8. Ribeiro CA. L-5-hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo controlled study. Headache. 2000
Jun;40(6):451-56. [PMID: 10849040]
9. Nagata E, Shibata M, Hamada J, et al. Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. Headache. 2006 Apr;46(4):592-96. [PMID:
10. Nicolodi M, Sicuteri F. L-5-hydroxytryptophan can prevent nociceptive disorders in man. Adv Exp Med Biol. 1999;467:177-82. [PMID: 10721054]
11. Schott DA, Nicolai J, de Vries JE, et al. Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome?
Horm Res Paediatr. 2010;73(1):68-73. [PMID: 20190542]
12. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J
Clin Nutr. 1992 Nov;56:863-67. [PMID: 1384305]
13. Cangiano C, Laviano A, Del Ben M, et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic
patients. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. [PMID: 9705024]
14. Rondanelli M, Klersy C, Iadarola P, et al. Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual
spray formulation. Int J Obes (Lond). 2009 Oct;33(10):1174-82. [PMID: 19752879]
15. Lee MA, Nash JF, Barnes M, et al. Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans.
Psychopharmacology (Berl). 1991;103(2):258-64. [PMID: 1851310]
16. Mashchak CA, Kletzky OA, Spencer C, et al. Transient effect of L-5-hydroxytryptophan on pituitary function in men and women. J Clin Endocrinol Metab. 1983
17. Wyatt RJ, Zarcone V, Engelman K, et al. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol. 1971
Jun;30(6):505-09. [PMID: 4105646]
18. Bruni O, Ferri R, Miano S, et al. L -5-hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004 Jul;163(7):402-07. [PMID:15146330]